Parathyroid hormone signaling through low-density lipoprotein-related protein 6
نویسندگان
چکیده
منابع مشابه
Parathyroid hormone signaling through low-density lipoprotein-related protein 6.
Intermittent administration of PTH stimulates bone formation, but the precise mechanisms responsible for PTH responses in osteoblasts are only incompletely understood. Here we show that binding of PTH to its receptor PTH1R induced association of LRP6, a coreceptor of Wnt, with PTH1R. The formation of the ternary complex containing PTH, PTH1R, and LRP6 promoted rapid phosphorylation of LRP6, whi...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2008
ISSN: 0890-9369
DOI: 10.1101/gad.1702708